Antibacterial agents
AssigneeAchaogen, Inc.
InventorsBrian D. Patterson, Qing Lu, James Bradley Aggen, Paola Dozzo, Ramesh Annasaheb Kasar, Martin Sheringham Linsell, Timothy Robert Kane, Micah James Gliedt, Darin James Hildebrandt, Glenn A. McEnroe, Frederick Cohen
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Abstract
Antibacterial compounds of formula (I) are provided: as well as stereoisomers and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of such compounds.
Claims20
A pharmaceutical composition comprising a pharmaceutically acceptable carrier, diluent or excipient and a compound of formula I:
- or a stereoisomer or pharmaceutically acceptable salt thereof, wherein
- A is selected from the group consisting of:
- (a) substituted C1-C6 alkyl, wherein at least one substituent is hydroxy;
- and
- (b) substituted C3-C6 cycloalkyl, wherein at least one substituent is selected from hydroxy and hydroxyalkyl;
- G is selected from the group consisting of:
- and
- (g) phenyl;
- and
- D is selected from the group consisting of:
- wherein
- R1 and R2 are each independently selected from hydrogen and methyl;
- and
- E is —C(CH3)2SCH3, —C(CH3)2S(O)CH3, —C(CH3)2S(O)2CH3, or —C(O)NHCH3.
A compound having the following structure:
- or a stereoisomer or pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.