# US 9,700,851 B2 · Phenol crosslink for sensor membrane

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- Number: US 9,700,851 B2
- Document ID: US9700851B2
- Status: Granted
- Kind: B2
- Application number: 13/107,816
- Filed: 2011-05-13
- Published: 2012-03-22
- Granted: 2017-07-11
- Earliest claimed: 2010-05-13
- Assignees: WaveForm Technologies, Inc.
- Applicants: Yuan Wang; Raeanne Gifford
- Inventors: Yuan Wang; Raeanne Gifford
- Web page: https://patentgrep.com/patent/US9700851B2

## CPC

- B01D 71/72: Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, not provided for in a single one of the groups B01D71/46 - B01D71/70 {and B01D71/701 - B01D71/702}
- B01D 67/0006: {by chemical reactions (in-situ polymerisation, polycondensation, cross-linking or reaction for manufacturing composite membranes B01D69/125)}
- C12Q 1/003: {Functionalisation}
- G01N 27/3274: {Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration (coding of calibration information G01N33/48771)}
- A61B 5/14532: {for measuring glucose, e.g. by tissue impedance measurement}
- A61B 2562/12: Manufacturing methods specially adapted for producing sensors for in-vivo measurements
- B01D 2323/30: Cross-linking
- G01N 27/40: Semi-permeable membranes or partitions
- B01D: SEPARATION (separating solids from solids by wet methods B03B, B03D; by pneumatic jigs or tables B03B; by other dry methods B07; magnetic or electrostatic separation of solid materials from solid materials or fluids, separation by high-voltage electric fields B03C; centrifuges, vortex apparatus B04; presses per se for squeezing-out liquid from liquid-containing material B30B9/02; treatment of water C02F, e.g. softening by ion-exchange C02F1/42; {arrangements of air intake cleaners in gas turbine plants F02C7/05} ; arrangements or mounting of filters in air-conditioning, air-humidification or ventilation F24F13/28)
- C12Q: MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

Embodiments herein provide a membrane that is a product of a phenol crosslinked with one or more compounds containing an allyl group. The phenol may be electropolymerized with the allyl-containing compounds to form the crosslinked polymer. Suitable allyl-containing compounds include allylphenol, allylalcohol, allylamine, and allylcarbamide. A membrane may have one type of allyl-containing compound, or, alternatively, two or more types of compounds. As used in an analyte sensing device, a membrane formed from a crosslinked phenol may provide improved interference exclusion, peroxide response, stability, and/or solvent resistance.

## Claims

### Claim 1

An interference exclusion membrane, consisting essentially of phenol crosslinked by one or more of allylalcohol, allylamine, and allylcarbamide.

### Claim 2 (depends on 1)

The membrane of claim 1, wherein the phenol is crosslinked by one of allylalcohol, allylamine, and allylcarbamide.

### Claim 3 (depends on 2)

The membrane of claim 2, consisting essentially of phenol crosslinked by allylalcohol.

### Claim 4 (depends on 2)

The membrane of claim 2, consisting essentially of phenol crosslinked by allylamine.

### Claim 5 (depends on 2)

The membrane of claim 2, consisting essentially of phenol crosslinked by allylcarbamide.

### Claim 6 (depends on 1)

The membrane of claim 1, wherein the phenol is crosslinked by two of allylalcohol, allylamine, and allylcarbamide.

### Claim 7 (depends on 1)

An analyte sensor, comprising:
the interference exclusion membrane of claim 1; and
an electrically active electrode surface.

### Claim 8 (depends on 7)

The analyte sensor of claim 7, wherein the interference exclusion membrane is disposed on the electrically active electrode surface.

### Claim 9 (depends on 8)

The analyte sensor of claim 8, further comprising an enzyme layer disposed on the interference exclusion membrane.

### Claim 10 (depends on 7)

The analyte sensor of claim 7, further comprising an enzyme layer disposed on the electrically active electrode surface, wherein the interference exclusion membrane is disposed on the enzyme layer.

### Claim 11 (depends on 7)

The analyte sensor of claim 7, wherein the interference exclusion membrane is configured to provide interference exclusion, peroxide response, stability, and/or solvent resistance.