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US 9,700,650 B2Granted
Polysaccharide based hydrogels
AssigneeSpotLight Technology Partners LLC
InventorsGlen Gong, Suresh Subraya Pai, Scott Robert Sershen
Life of this patent
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Abstract
Polysaccharide based hydrogel compositions and methods of making and using the same are provided. The subject polysaccharide based hydrogel compositions are prepared by combining a polysaccharide component with a hydrophilic polymer and a cross-linking agent. Also provided are kits and systems for use in preparing the subject compositions.
Claims16
A hydrogel composition, comprising
- carboxymethylchitosan having a molecular weight of less than or equal to 5,000 Dalton, a degree of deacetylation of 70% to 99%, an electrophilic group, and at least two nucleophilic groups, wherein carboxymethylchitosan is soluble in an aqueous solution;
- a multifunctional, multi-armed polyethylene glycol polymer of a molecular weight of 5,000 Dalton to 30,000 Dalton, and comprising at least two nucleophilic groups;
- and
- a multifunctional, multi-armed crosslinker of polyethylene glycol having a molecular weight of 5,000 Dalton to 30,000 Dalton, and comprising at least two electrophilic groups;
- wherein the multifunctional, multi-armed polyethylene glycol polymer comprises ester groups to provide for degradation via hydrolysis and
- wherein the hydrogel composition comprises:
- a covalent bond between carboxymethylchitosan and the multifunctional multi-armed polyethylene glycol polymer;
- a covalent bond between carboxymethylchitosan and the multifunctional multi-armed crosslinker and
- a covalent bond between the multifunctional multi-armed polyethylene glycol polymer and the multifunctional multi-armed crosslinker.
6 more elements
A hydrogel composition, comprising:
- dicarboxyl chitosan having a molecular weight of less than or equal to 5,000 Dalton, a degree of deacetylation of 70% to 99%, an electrophilic group, and at least two nucleophilic groups, wherein the dicarboxyl chitosan is soluble in an aqueous solution;
- a multifunctional, multi-armed polyethylene glycol polymer of a molecular weight of 5,000 Dalton to 30,000 Dalton, and comprising at least two nucleophilic groups;
- and
- a multifunctional, multi-armed crosslinker of polyethylene glycol having a molecular weight of 5,000 Dalton to 30,000 Dalton, and comprising at least two electrophilic groups;
- wherein the multifunctional, multi-armed polyethylene glycol polymer comprises ester groups to provide for degradation via hydrolysis and
- wherein the hydrogel composition comprises:
- a covalent bond between dicarboxyl chitosan and the multifunctional multi-armed polyethylene glycol polymer;
- a covalent bond between dicarboxyl chitosan and the multifunctional multi-armed crosslinker and
- a covalent bond between the multifunctional multi-armed polyethylene glycol polymer and the multifunctional multi-armed crosslinker.
6 more elements
Dependencies are inferred from the claim text.