Microorganisms carrying a tumor antigen
AssigneeGlycotope GmbH
InventorsSteffen Goletz, Philippe Ulsemer, Kawe Toutounian
Life of this patent
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Abstract
The present invention pertains to microorganisms of the species Bacteroides xylanisolvens expressing a core-1 antigen on their surface. These microorganisms are in particular useful for the prophylaxis and treatment of core-1 positive diseases and are particularly characterized by a stable, homogenous high core-1 expression. Also provided are pharmaceutical compositions which comprise respective core-1 positive microorganisms or fractions thereof.
Claims12
An isolated pasteurized or lyophilized core-1 positive microorganism of the species Bacteroides xylanisolvens, wherein said microorganism is recognized by at least one core-1 specific antibody;
- wherein said core-1 positive microorganism is of the strain Coreotics, deposited as DSM 25004, a microorganism derived therefrom or a homolog thereof, wherein the microorganism derived from the strain Coreotics or the homolog of the strain Coreotics has the following characteristics:
- a) it belongs to the species of Bacteroides xylanisolvens;
- and
- b) in a cell culture of said microorganism, at least 50% of the microorganisms have a core-1 antigen expression level which is at least 50% of the average core-1 antigen expression of the strain Coreotics.
A composition comprising microorganisms, wherein at least 90% of the microorganisms are (A) core-1 positive microorganisms of the strain Coreotics, deposited as DSM 25004, microorganisms derived therefrom or homologs thereof, and/or (B) a core-1 positive lysate thereof or a core-1 positive fraction thereof;
- wherein the microorganisms derived from the strain Coreotics or the homologs of the strain Coreotics have the following characteristics:
- a) they belong to the species of Bacteroides xylanisolvens;
- and
- b) in a cell culture of said microorganism, at least 50% of the microorganisms have a core-1 antigen expression level which is at least 50% of the average core-1 antigen expression of the strain Coreotics;
- and wherein the core-1 positive fraction of the microorganism is selected from the group consisting of a cell wall preparation, an envelope preparation, a lipopolysaccharide preparation, a capsule preparation and a capsule polysaccharide preparation.
Dependencies are inferred from the claim text.