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US 9,700,581 B2Granted
Urine stem cells for skeletal muscle generation and uses thereof
AssigneeWake Forest University Health Sciences
InventorsYuanyuan Zhang, Emmanuel C. Opara
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Abstract
Provided herein are methods of treating a subject in need of treatment for a urological condition including administering urine stem cells to said subject in a treatment effective amount; and, in conjunction therewith, administering growth factors to said subject in an amount effective to promote differentiation of said stem cells into skeletal muscle cells. Compositions useful for the same are also provided.
Claims13
A method of treating stress urinary incontinence or vesicoureteral reflux in a subject in need thereof, comprising:
- administering urine stem cells to the urethra of said subject in a treatment effective amount;
- and, in conjunction therewith,
- administering growth factors to said subject in an amount effective to promote differentiation of said stem cells into skeletal muscle cells,
- wherein said growth factors comprise an angiogenic growth factor, a skeletal myogenic growth factor, and a neurogenic growth factor, and wherein said growth factors are selected from the group consisting of VEGF, IGF-1, FGF-1, PDGF, HGF, and NGF.
1 more element
Dependencies are inferred from the claim text.