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US 9,696,302 B2Granted
Methods for isolating a target analyte from a heterogeneous sample
AssigneeDNAE Group Holdings Limited
InventorsSergey A. Dryga, Victor C. Esch, Lisa-Jo Ann Clarizia, Eddie W. Adams, Thearith H. Ung, Ravil A. Sitdikov
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Abstract
The invention generally relates to methods of using compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen, and magnets to isolate a pathogen from a body fluid sample.
Claims13
A method for isolating pathogen from a heterogeneous sample, the method comprising:
- providing a vessel that contains a heterogeneous sample comprising pathogen, the vessel being coupled to a fluidic device that comprises a channel and a magnet;
- introducing to the sample in the vessel a cocktail comprising a plurality of magnetic particles, conjugated to antibodies that bind said pathogen, thereby forming a mixture comprising antibody-bound pathogen particles;
- flowing the mixture from the vessel through a channel in the fluidic device such that said magnetic particles attach to said magnet;
- and
- separating antibody-bound pathogen attached to said magnet from other components in the sample.
2 more elements
Dependencies are inferred from the claim text.