Benzoxazinone derivatives for treatment of skin diseases
AssigneeSixera Pharma AB
InventorsFredrik Wagberg, Goran Leonardsson
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Abstract
The present invention relates to methods and compositions for inhibiting the activity of skin proteases, especially human kallikrein 7 (KLK7), human kallikrein 5 (KLK5), and human kallikrein 14 (KLK14). More specifically, the invention relates to the use of substituted 3,1-benzoxazin-4-ones being selective inhibitors of human skin kallikreins for the treatment of skin diseases, more specifically for the treatment of inflammatory skins diseases, especially Netherton syndrome.
Claims5
A compound according to Formula I
- wherein R is —S—CH3 or —Cl, or a pharmaceutically acceptable salt thereof.
The compound 6-Ethoxy-7-methoxy-2-(2-methylsulfanylphenyl)-3,1-benzoxazin-4-one.
The compound 2-(2-Chlorophenyl)-6-ethoxy-7-methoxy-3,1-benzoxazin-4-one.
Dependencies are inferred from the claim text.