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US 9,688,977 B2Granted
Engineered phosphoglucose isomerase proteins with a protease cleavage site
AssigneeGreenLight Biosciences, Inc.
InventorsWilliam Jeremy Blake, Drew S. Cunningham
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Abstract
Various aspects and embodiments herein relate to recombinant proteins with at least one protease recognition sequence that can be inactivated by a cognate protease and methods of preparing such proteins. In some embodiments, recombinant phosphoglucose isomerase (Pgi) proteins are provided. In other embodiments, recombinant phosphotransacetylase (Pta) proteins are provided. In yet other embodiments, recombinant transketolase A (TktA) proteins are provided.
Claims4
A recombinant protein comprising a polypeptide derived from SEQ ID NO:
- 17, said polypeptide comprising a human rhinovirus 3C protease recognition sequence located between amino acids 526 and 527 of SEQ ID NO:17 wherein, said polypeptide has at least 95% identity with SEQ ID NO:
- 25 and has phosphoglucose isomerase activity.
Dependencies are inferred from the claim text.