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US 9,688,727 B2Granted
Desmoglein 2 (DSG2) binding proteins and uses therefor
AssigneeUniversity of Washington
InventorsAndre Lieber, Hongjie Wang
Life of this patent
Estimating the term…
Abstract
The present invention provides recombinant adenoviral compositions and methods for their use in treating disorders associated with epithelial tissues.
Claims28
A recombinant AdB-2/3 fiber polypeptide, comprising:
- (a) one or more AdB-2/3 fiber polypeptide shaft domain motifs;
- (b) an AdB-2/3 fiber polypeptide knob domain operatively linked to and located C-terminal to the one or more AdB-2/3 fiber polypeptide shaft domain motifs, wherein the AdB-2/3 fiber polypeptide knob domain comprises the peptide of SEQ ID NO:4 TLWTGPKPEA NCIIEYGKQN PDSKLTLILV KNGG(I/L)VNGYV TLMGASDYVN TLFKNKNVSI NVELYFDATG HILPDSSSLK TDLEX2 X3YKQTAD X4 SARGFMP STTAYPFX5LP NAGTHNX6NX7 IFGQCYY X8 ASDGALFPLEVTV MLNKRLPDSR TSYVMTFLWS LX9AGLAPETT QATLITSPFT FSYIREDD (SEQ ID NO:4),
- wherein:
- X2 is H, L, or P;
- X3 is K or E;
- X4 is T, F, S, or L;
- X5 is V, or D;
- X6 is E or G;
- X7 is Y or F;
- X8 is T, K, or E;
- and
- X9 is N or S;
- and
- wherein at least one of the following is true:
- X2 is P;
- X3 is E;
- X4 is S, or L;
- X5 is D;
- X6 is G;
- X7 is F;
- X8 is E;
- or
- X9 is S;
- and
- (c) one or more non-AdB-2/3-derived dimerization domains operatively linked to and located N-terminal to the one or more AdB-2/3 fiber polypeptide shaft domain motifs.
22 more elements
Dependencies are inferred from the claim text.