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US 9,688,718 B2Granted
Nanolipoprotein particles comprising hydrogenases and related products, methods and systems
AssigneeLawrence Livermore National Security, LLC
InventorsSarah E. Baker, Brett A. Chromy, Paul Henderson, Paul D. Hoeprich, Jr.
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Abstract
Provided herein are nanolipoprotein particles that comprise a membrane associated hydrogenase and related assemblies, devices, methods and systems.
Claims23
A nanolipoprotein particle comprising
- a membrane associated hydrogenase,
- a membrane forming lipid, and
- a scaffold protein,
- wherein the membrane associated hydrogenase is heteromeric and multimeric;
- and
- wherein the nanolipoprotein particle further comprises a cell membrane fragment, the cell membrane fragment comprising the membrane associated heteromeric and multimeric hydrogenase in a catalytically active form,
- the membrane forming lipid and the scaffold protein are at a mass ratio between 1:1 and 20:1 and the scaffold protein and the membrane associated heteromeric and multimeric hydrogenase are at a mass ratio between 1:0.025 and 1:1.
4 more elements
A nanolipoprotein particle comprising
- a membrane associated hydrogenase,
- a membrane forming lipid, and
- a scaffold protein,
- wherein the membrane associated hydrogenase is heteromeric and multimeric in a catalytically active form;
- and
- wherein the nanolipoprotein particle is obtained from a cell membrane fragment, the cell membrane fragment comprising the membrane associated heteromeric and multimeric hydrogenase,
- the membrane forming lipid and the scaffold protein are at a mass ratio between 1:1 and 20:1 and the scaffold protein and the membrane associated heteromeric and multimeric hydrogenase are at a mass ratio between 1:0.025 and 1:1.
4 more elements
Dependencies are inferred from the claim text.