Geranyl geranyl acetone analogs and uses thereof
AssigneesNyken Holding B.V., Rijksuniversiteit Groningen, Academisch Ziekenhuis Groningen
InventorsBianca Johanna Josephina Maria Brundel, Hermannus Steen, André Heeres, Johannes Paulus Gerardus Seerden
Life of this patent
Estimating the term…
Abstract
The invention relates to novel therapeutic compounds, more in particular to biologically active analogs and uses thereof as medicament, for instance for the treatment of atrial fibrillation. Provided is a compound of the general formula (formula I) wherein R1 is H or a saturated or unsaturated aliphatic moiety comprising 1 to 8 C-atoms; and X is selected from the group consisting of moieties X1, X2, X3, X4, X5 and X6. Exemplary uses include the prevention or therapeutic treatment of a HSF1-mediated disease.
Claims8
A pharmaceutical composition comprising a compound of the general formula I
- wherein
- R1 is H or a saturated or unsaturated aliphatic moiety comprising 1 to 8 C-atoms;
- and
- wherein R10 is a C1-C5 alkyl group, optionally substituted with one or more selected from the group consisting of halogen, oxo, sulfo, hydroxyl, —CN, alkoxy, amino, amido, aryl, substituted aryl, hetero-aryl, substituted hetero-aryl, cyclo-alkyl, heterocycloalkyl, nitro, carboxylic acid and carboxylic ester;
- or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier and/or adjuvant.
Dependencies are inferred from the claim text.