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AssigneeThe Curators of the University of Missouri
InventorsBumsuk Hahm, Young-Jin Seo, Stephen Alexander, Vijayan Madhuvanthi
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The present invention relates to compounds and methods for the prevention or treatment of infections by negative strand RNA viruses, such as influenza virus and measles virus, wherein said compounds delay or inhibit viral replication by modulating the level or activity of a polypeptide involved in the synthesis or degradation of sphingosine-1-phosphate (S1P) in a cell, tissue, or subject. The methods involve administration of one or more compounds which modulate the level of gene expression, where the gene encodes a polypeptide involved in regulating the metabolic level of S1P, or modulate the level or activity of a polypeptide involved in regulating the metabolic level of S1P, such as sphingosine kinase (SK) and S1P lyase (SPL). Exemplary methods are directed towards reducing the level of SW by reducing the level or activity of one or more SKs, increasing the level or activity of one or more SPLs, or a combination of both steps.
A method of inhibiting the production of a negative-strand RNA virus in a eukaryotic cell, comprising administering a composition comprising one or more agents which modulate the level or activity of a polypeptide involved in the synthesis or degradation of sphingosine-1-phosphate in said cell, wherein said negative-strand RNA virus is in a family selected from the group consisting of Orthomyxoviridae, Paramyxoviridae, Rhabdoviridae, Filoviridae, Bornaviridae, and Bunyaviridae.
A composition for inhibiting the production of a negative-strand RNA virus in a eukaryotic cell, comprising an effective amount of an S1P-modulating agent, wherein the S1P-modulating agent decreases the level of S1P within said cell in a sample of cells contacted with the S1P-modulating agent compared to control sample of cells not contacted with the S1P-modulating agent, wherein said negative-strand RNA virus is in a family selected from the group consisting of Orthomyxoviridae, Paramyxoviridae, Rhabdoviridae, Filoviridae, Bornaviridae, and Bunyaviridae.
A method for treating, preventing, or ameliorating one or more symptoms associated with a negative-strand RNA virus infection in a subject, said method comprising administering to said subject in need thereof, a prophylactically- or therapeutically-effective amount of a composition comprising one or more agents which modulate the level or activity of a polypeptide involved in the synthesis or degradation of sphingosine-1-phosphate in said subject, wherein said negative-strand RNA virus is in a family selected from the group consisting of Orthomyxoviridae, Paramyxoviridae, Rhabdoviridae, Filoviridae, Bornaviridae, and Bunyaviridae.
Dependencies are inferred from the claim text.