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US 9,683,247 B2Granted
Microbial production of alkanolamides and amidoamines and uses thereof
AssigneeReg Life Sciences, LLC
InventorsJason J. Lutes, Stephen del Cardayre
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Abstract
The disclosure relates to a recombinant microorganism engineered to express an enzyme which catalyzes the conversion of a primary amine and an acyl thioester to a fatty amide. The disclosure further encompasses a method of producing a fatty amide by culturing the recombinant microorganism in the presence of a carbon source.
Claims21
A recombinant microorganism comprising an exogenous nucleic acid sequence encoding a palmitoylputrescine synthase (PPS) haying at least 90% sequence identity to the amino acid sequence of SEQ. ID. NO.:
- 1, wherein the PPS catalyzes the conversion of a primary amine and an acyl thioester to a fatty amide, wherein the microorganism further expresses an exogenous thioesterase (EC 3.12.14 or EC 3.1.1.5) and is cultured in the presence of a carbon source.
Dependencies are inferred from the claim text.