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US 9,683,233 B2Granted
Artificial nucleic acid molecules for improved protein or peptide expression
AssigneeCureVac AG
InventorAndreas Thess
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Abstract
The invention relates to an artificial nucleic acid molecule comprising at least one 5′UTR element which is derived from a TOP gene, at least one open reading frame, and preferably at least one histone stem-loop. Optionally the artificial nucleic acid molecule may further comprise, e.g. a poly(A)sequence, a poyladenylation signal, and/or a 3′UTR. The invention further relates to the use of such an artificial nucleic acid molecule in gene therapy and/or genetic vaccination.
Claims22
An artificial nucleic acid molecule comprising, from 5′ to 3′:
- (a) a 5′-untranslated region element (5′UTR element) of a TOP gene;
- (b) at least one open reading frame (ORF);
- and
- (c) at least one histone stem-loop sequence.
1 more element
Dependencies are inferred from the claim text.