Inhibitory peptides of viral infection
AssigneeUniversity of Tennessee Research Foundation
InventorsJonathan S. Wall, Timothy E. Sparer, Stephen J. Kennel
Life of this patent
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Abstract
Disclosed are methods of treating and/or inhibiting a viral infection in a subject. The methods include administering a therapeutically effective amount of heparin-binding peptide. Also disclosed herein are methods for blocking viral binding to a cell. Further disclosed are anti-viral compositions for administration to a subject infected with a virus. Administration of the anti-viral composition inhibits viral infection of the subject.
Claims20
A method for reducing a viral infection in a subject, comprising:
- selecting a subject in whom the viral infection is to be reduced;
- and
- administering to the subject an effective amount of a heparin-binding peptide comprising an amino acid sequence at least 95% identical to the amino acid sequence set forth as any one of SEQ ID NOs:
- 1-10, thereby reducing the viral infection in the subject.
A method for reducing binding of a virus to a cell, comprising:
- contacting a cell with an effective amount of a heparin-binding peptide, the heparin-binding peptide comprising an amino acid sequence at least 95% identical to the amino acid sequence set forth as any one of SEQ ID NOs:
- 1-10.
An anti-viral composition, the composition comprising:
- a heparin-binding peptide, the heparin-binding peptide comprising an amino acid sequence at least 95% identical to the amino acid sequence set forth as any one of SEQ ID Nos. 3-10.
Dependencies are inferred from the claim text.