Drug delivery product and methods

A particulate delivery system comprising an extracted yeast cell wall comprising less than 90 weight percent beta-glucan, a payload molecule and a payload trapping molecule, wherein the payload trapping molecule is contained within an interior space defined by the extracted yeast cell wall, wherein the payload trapping molecule is present in an amount sufficient to facilitate retention of the payload molecule within the extracted yeast cell wall, and wherein the payload molecule is selected from the group consisting of a polynucleotide and a small organic active agent.