Postprandial gastrokinetic agent
AssigneesZeria Pharmaceutical Co., Ltd., Saitama University
InventorsTakafumi Sakai, Ichiro Sakata, Kayuri Kuroda, Makoto Yoshimura
Life of this patent
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Abstract
To provide a therapeutic agent for gastrointestinal disorder such as diabetic gastroparesis. A postprandial gastrokinetic agent containing (A) ghrelin or a ghrelin agonist and (B) motilin or a motilin agonist as active ingredients, in which both the ingredients (A) and (B) are administered so as to act on the stomach after food intake.
Claims19
A method for enhancing postprandial gastric motility, comprising:
- administering an ingredient (A) which is ghrelin or a ghrelin agonist and an ingredient (B) which is motilin or a motilin agonist to a subject in need thereof such that an effective blood level of each of the ingredients (A) and (B) is achieved after food intake,
- wherein after food intake is within about 30 minutes immediately after intake of a meal,
- timing of the administering of each of the ingredients (A) and (B) is determined in consideration of a time to achieve the effective blood level, which is about 20 minutes to about 60 minutes after oral administration and about 10 minutes after intravenous administration, and
- in the administering of the ingredient (A) and the ingredient (B), the dose of the ingredient (A) is 1/50 to 1/500 of an effective dose for administering the ingredient (A) alone, and the dose of the ingredient (B) is ⅓ to 1/30 of an effective dose for administering the ingredient (B) alone.
A method of treating a human patient having a disease selected from the group consisting of diabetic gastroparesis, postoperative gastroparesis, and functional dyspepsia, comprising:
- administering ghrelin or a ghrelin agonist and motilin or a motilin agonist to the human patient,
- wherein the dose of ghrelin or a ghrelin agonist is 1/50 to 1/500 of an effective dose for administering ghrelin or the ghrelin agonist alone, and the dose of motilin or a motilin agonist is ⅓ to 1/30 of an effective dose for administering motilin or the motilin agonist alone.
Dependencies are inferred from the claim text.