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US 9,677,112 B2Granted
β-lactamase substrates and methods of their use for the diagnosis of tuberculosis
AssigneesThe Texas A&M University System, The Board of Trustees of the Leland Stanford Junior University
InventorsJianghong Rao, Jeffrey D. Cirillo, Hexin Xie, James C. Sacchettini
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Abstract
β-Lactamase substrates and methods for using the substrates to detect β-lactamase diagnose tuberculosis.
Claims22
A compound having the formula:
- or an ester or a salt thereof,
- wherein
- A is selected from the group consisting of:
- (a) substituted and unsubstituted C6-C10 aryl;
- and
- (b) substituted and unsubstituted C3-C7 heteroaryl;
- R1 is selected from the group consisting of:
- (a) methoxy;
- and
- (b) ethoxy;
- R2 is selected from the group consisting of hydrogen, C1-C3 alkyl, C1-C3 alkyl substituted with one or more halogens, and substituted piperazine;
- X is O or S;
- Ra, Rb, Rc, and Rd are independently selected from the group consisting of hydrogen, halogen, nitro, C1-C3 alkyl, and C1-C3 alkyl substituted with one or more halogens;
- Z is a moiety that provides a fluorescent, luminescent, or colorimetric signal when released from the compound;
- and
- n is 0 or 1.
13 more elements
Dependencies are inferred from the claim text.