Use of a cysteine protease of plasmodium vivax
AssigneeSamsung Electronics Co., Ltd.
InventorsYoon Kong, Byoung-Kuk Na, Seon-Hee Kim, Young-An Bae
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Abstract
A use of vivapain-4 (VX-4), which is a cysteine protease of Plasmodium vivax, showing pH-dependent switching of substrate specificity, is provided. More specifically, a method of treating a parasitic disease caused by Plasmodium vivax by inhibiting VX-4; a method of screening a protease inhibitor acting on VX-4, wherein the protease inhibitor is useful as an anti-malarial agent acting on Plasmodium species, for example, Plasmodium vivax; and a method of identifying the activity of VX-4, are provided.
Claims8
A cysteine protease, wherein the amino acid sequence of the cysteine protease is the amino acid sequence from SEQ ID NO:
- 1, and wherein glutamic acid at 180th position of SEQ ID NO:
- 2, which is a mature domain of SEQ ID NO:
- 1, is deleted, or substituted with an amino acid selected from the group consisting of arginine, histidine, lysine, alanine, isoleucine, leucine, methionine, phenylalanine, proline, tryptophane, valine, and cysteine.
Dependencies are inferred from the claim text.