Anti-CD100 neutralizing antibodies and methods of using the same
AssigneeVaccinex, Inc.
InventorsErnest S. Smith, Terrence Lee Fisher
Life of this patent
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Abstract
Compositions and methods are provided for treating diseases associated with CD100, including certain autoimmune diseases, inflammatory diseases, and cancers. In particular, anti-CD100 monoclonal antibodies have been developed to neutralize CD100.
Claims28
An isolated antibody or antigen-binding fragment thereof comprising a heavy chain variable region (VH) and a light chain variable region (VL), wherein the VH comprises the amino acid sequence SEQ ID NO:
- 9, and wherein the antibody or fragment thereof can specifically bind to CD100.
An isolated antibody or antigen-binding fragment thereof comprising a heavy chain variable region (VH) and a light chain variable region (VL), wherein the VL comprises the amino acid sequence SEQ ID NO:
- 17, and wherein the antibody or fragment thereof can specifically bind to CD100.
Dependencies are inferred from the claim text.