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US 9,676,747 B2Granted
Hepatitis B antiviral agents
AssigneeNovira Therapeutics, Inc.
InventorsGeorge D. Hartman, Osvaldo A. Flores
Life of this patent
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Abstract
The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of at least one compound of the invention.
Claims18
A compound of Formula V:
- or a pharmaceutically acceptable salt thereof;
- wherein
- R4 is H or C1-C6 alkyl;
- G1 is H or C1-C6 alkyl;
- each R5 is independently selected at each occurrence from the group consisting of OH, C1-C6 alkyl, halo, —CN, —NO2, C1-C6 chloroalkyl, —C1-C6 dichloroalkyl, —C1-C6 trichloroalkyl, —C1-C6 fluoroalkyl, —C1-C6 difluoroalkyl and —C1-C6 trifluoroalkyl;
- R2 is independently selected at each occurrence from the group consisting of halo, —OH, —CN, —NO2, —C1-C6 alkyl, —C1-C6 alkoxy, —C1-C6 fluoroalkyl, —C1-C6 heteroalkyl, and C(O)—C1-C6 alkyl;
- n is 1, 2, 3, 4, 5, or 6;
- x is selected from the group consisting of 0, 1, 2, 3 and 4;
- and
- y is selected from the group consisting of 1, 2, and 3.
7 more elements
A compound having the formula
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.