Factor XIa inhibitors

A compound of the formula:

• wherein Z is a five or six membered aryl or five or six membered heteroaryl ring, wherein said aryl or heteroaryl rings are optionally substituted with one to three substituents selected from the group consisting of C1-6 alkyl, C3-6 cycloalkyl, halo, cyano or hydroxy, wherein said alkyl and cycloalkyl groups are optionally substituted with one to three groups independently selected from halo and hydroxy;
• L is selected from the group consisting of CONH, NHC(O) or heteroaryl, which is optionally substituted with halo or methyl;
• M is selected from the group consisting of aryl and heteroaryl, wherein said aryl and heteroaryl groups are optionally substituted with halo or methyl;
• R1 is hydrogen, C1-6 alkyl, C3-6 cycloalkyl, halo, cyano or hydroxy, wherein said alkyl and cycloalkyl groups are optionally substituted with one to three groups independently selected from the group consisting of halo and hydroxy;
• R2 is independently selected from the group consisting of hydrogen, halo, cyano, hydroxy, R7, OR3, C1-6 alkyl, C(O)OH, C(O)OR3, (R3)C(O)OH, (R3)C(O)OR4, NR5R6, (R3)NR5R6, NHCOR3, NHC(O)OR3, NHC(O)OR7, NHC(O)O(R3)R7, NHC(O)O(R3)OR4, NHC(O)O(R3)C(O)OH, (R3)NHC(O)OR4, NHCONR5R6, NHSO2R3, CONR5R6, CH2CONR5R6 and NHCONH(R3)R7;
• R3 is hydrogen or C1-6 alkyl, wherein said alkyl is optionally substituted with one to three halo or hydroxy;
• R4 is hydrogen or C1-6 alkyl, wherein said alkyl is optionally substituted with one to three halo;
• R5 is hydrogen or C1-6 alkyl;
• R6 is hydrogen or C1-6 alkyl;
• R7 is C3-6 cycloalkyl, heterocyclyl or heteroaryl, wherein said heteroaryl is optionally substituted with one or two groups independently selected from the group consisting of halo, C1-3 alkyl and C3-6 cycloalkyl;
• x is an integer between zero and three;
• y is an integer between zero and three;
• or a pharmaceutically acceptable salt thereof.