Therapeutic phages and methods for delivery of nucleic acids for therapeutic uses

A method for delivering a nucleic acid sequence comprising the steps of:

• administering to a subject a bacteriophage-derived particle including at least one nucleic acid sequence and a bacterial origin of replication and a receptor binding protein where the particle is devoid of one or more functional phage replication genes rendering it incapable of independent production of phage progeny;
• wherein the receptor binding protein attaches the particle to a target bacteria in a microbiome;
• and
• wherein the nucleic acid sequence is expressed in the target bacteria where the expression of the nucleic acid sequence and the expressed nucleic acid sequence are non-lethal to the target bacteria and the expressed nucleic acid sequence produces a therapeutic effect to the subject.