Compounds and methods for biofilm disruption and prevention
AssigneeUniversity of Newcastle Upon Tyne
InventorsJames Grant Burgess, Michael John Hall, Reindert Nijland
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Abstract
The invention relates to compounds, compositions and methods for biofilm disruption and prevention. In particular, the invention relates to pharmaceutical compositions for the disruption of biofilm and prevention of biofilm in patients. The invention also relates to anti-biofouling compositions for the disruption of biofilm and prevention of biofilm on surfaces. The invention also relates to the removal of biological material from surfaces. The compositions of the invention include microbial deoxyribonucleases.
Claims15
An anti-biofouling composition for disrupting or preventing a biofilm formation comprising a biofilm-modulating dose of an isolated NucB deoxyribonuclease, an enzyme, and an anionic or non-ionic surfactant, wherein the NucB deoxyribonuclease is the amino acid sequence of SEQ ID NO:
- 4 or a deoxyribonuclease sequence that is at least 95% identical to SEQ ID NO:
- 4, and wherein said composition is formulated as a washing powder or a cleaning solution.
Dependencies are inferred from the claim text.