Microneedle device having a peptide therapeutic agent and an amino acid, methods of making and using the same
Assignee3M Innovative Properties Company
InventorsYing Zhang, Percy T. Fenn, Peter R. Johnson
Life of this patent
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Abstract
A medical device including an array of microneedles and a coating disposed on or within the microneedles and a method of making such a device are disclosed. The coating includes a peptide therapeutic agent and an amino acid. A method of stabilizing a peptide therapeutic agent with an amino acid on an array of microneedles is also disclosed. In some cases, the peptide therapeutic agent and the amino acid either both have a net positive charge or both have a net negative charge. In some cases, the peptide therapeutic agent is histidine.
Claims20
A medical device comprising:
- an array of microneedles;
- and
- a coating on or within at least a portion of the microneedles, wherein the coating comprises:
- a peptide therapeutic agent;
- and
- an amino acid,
- wherein the coating is substantially free of sorbitol, and wherein one of the following is true:
- the peptide therapeutic agent has a net positive charge at a pH in a range from 7 to 7.4, and the amino acid has a net positive charge at the pH;
- or
- the peptide therapeutic agent has a net negative charge at a pH in a range from 7 to 7.4, and the amino acid has a net negative charge at the pH.
A medical device comprising:
- an array of microneedles;
- and
- a coating on or within at least a portion of the microneedles, wherein the coating comprises:
- a peptide therapeutic agent;
- and
- histidine,
- wherein the molar ratio of the histidine to the peptide therapeutic agent is less than 2.1.
Dependencies are inferred from the claim text.