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US 9,675,571 B2Granted
Inhibitors of indoleamine 2,3-dioxygenase (IDO)
AssigneeBristol-Myers Squibb Company
InventorsJames Aaron Balog, Audris Huang, Bin Chen, Libing Chen, Steven P. Seitz, Amy C. Hart, Jay A. Markwalder
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Abstract
There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
Claims11
A compound of formula (I)
- where
- X is
- E is NH or CH2;
- W is CR10;
- Y is CR11;
- V is CR12;
- is C3-C8 cycloalkyl;
- R1 is C1-C10 alkyl optionally substituted with halo or phenyl wherein said phenyl may be optionally substituted with halo;
- R2 is COOH, heteroaryl or CONHSO2R14;
- R3 is H, C1-C10 alkyl or halo;
- R4 is H, C1-C10 alkyl, or halo;
- R6 is H;
- R7 and R8 are independently selected from the group consisting of C1-C10 alkyl optionally substituted with halo or phenyl, wherein said phenyl may be optionally substituted with halo, C1-C10 alkoxy, C1-C10-alkoxy-C1-C10-alkyl, C3-C8 cycloalkyl, aryl optionally substituted with halo;
- R9 is aryl, C1-C10 alkylaryl, C3-C8 cycloalkylaryl, C1-C10 alkoxyaryl, C1-C10 alkyl heteroaryl, heteroaryl, or
- wherein R9 may be substituted with at least one alkyl, halo, alkoxy, CN, or haloalkyloxy;
- R10 is H or halo;
- R11 is H or halo;
- and
- R12 is H, C1-C10 alkyl, or C2-C10 alkenyl;
- R14 is CF3, C3-C8 cycloalkyl or C1-C10 alkyl;
- and/or a stereoisomer, tautomer or a pharmaceutically acceptable salt thereof.
18 more elements
Dependencies are inferred from the claim text.