Biomarker-based methods for identifying and formulating compositions that improve skin quality and reduce the visible signs of aging in skin
AssigneeThe Procter & Gamble Company
InventorsQing Stella, Karl Shiqing Wei, Cynthia Ann Garza, Kenneth Robert Wehmeyer, Rohan Lalith Wimalasena
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Abstract
In various embodiments, provided are methods for selecting and formulating compositions for treating and maintaining the quality of skin, wherein a composition is selected for use in a personal care product based on its demonstrated biological effect to improve skin quality as evidenced by one or more biomarker changes that correlate with improvement as evidenced by one or more objective measurements of skin health.
Claims6
A screening method for identifying a body wash composition as effective at improving the health of human skin, comprising:
- a. during a treatment period comprising at least one treatment, contacting a skin surface of a human subject with a body wash composition during a treatment period, wherein the body wash composition is washed off after each application;
- b. at least once during the treatment period extracting from the epidermis of the human subject (i) at least one biomarker selected from the group consisting of IL1 rα and IL 1α, (ii) at least one biomarker selected from the group consisting of Trans-Urocanic Acid, Citrulline, Glycine, Histidine, Ornithine, Proline, 2 Pyrrolidone 5 acid, and Serine,(iii) at least one biomarker that is a ceramide, (iv) at least one biomarker that is a fatty acid, and (v) total protein;
- c. measuring an amount of each biomarker extracted;
- and
- d. identifying the body wash composition as effective if the amount of each biomarker is shifted in a direction of improved skin health with total protein decreasing.
Dependencies are inferred from the claim text.