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US 9,671,344 B2Granted
High-density biochemical array chips with asynchronous tracks for alignment correction by moiré averaging
AssigneeComplete Genomics, Inc.
InventorBryan P. Staker
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Abstract
An array chip useful for biochemical assays is provided wherein the chip includes a field region arranged with attachment sites according to a first pitch and at least one track region having a one-dimensional spot pattern arranged according to a second pitch that is less dense and is a non-integer multiple of the first pitch so that one-dimensional Moiré averaging may be applied in the track region, thereby to attain alignment of the chip to the optical instrumentation with a higher density of attachment sites.
Claims19
A chip for assays comprising:
- a solid planar substrate;
- a two-dimensional array of experiment sites on the substrate, characterized as having a uniform distance between adjacent experiment sites in each row and between adjacent experiment sites in each column;
- a linear array of alignment sites on the substrate, characterized as having a uniform distance between adjacent alignment sites;
- and
- a site free band separating the two-dimensional array and the linear array, the site free band having a width that is greater than the uniform distance between adjacent experiment sites in the two dimensional array;
- wherein experiment sites in the two dimensional array and alignment sites in the linear array have a surface that is chemically functionalized to bind and retain nucleic acid macromolecules;
- wherein outside the experiment sites and the alignment sites, the substrate has a surface that resists binding of nucleic acid macromolecules;
- and
- wherein the uniform distance between sites in the linear array is a non-integral multiple of the uniform distance between the rows and between the columns in the two-dimensional array.
6 more elements
Dependencies are inferred from the claim text.