Back to results
US 9,670,236 B2Granted
Class of HDAC inhibitors expands the renal progenitor cells population and improves the rate of recovery from acute kidney injury
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsNeil Hukriede, Billy W. Day, Lee A. McDermott
Life of this patent
Estimating the term…
Abstract
Compounds and compositions are provided that inhibit histone deacylase activity and which expand renal progenitor cell populations and improve kidney function in a damaged kidney. Methods of use of the compounds and compositions are provided.
Claims31
A compound having the formula selected from the group consisting of:
- or a pharmaceutically acceptable salt thereof.
A compound having the formula:
- in which
- R is O,
- R1 is methoxy or —NHR4 where R4 is OH, aminophenyl, hydroxyphenyl, hydroxypyridinyl, aminopyridinyl, alkyl hydroxypyridinyl, or haloalkyl hydroxyphenyl,
- R2 is phenyl, benzyl, 4-methoxybenzyl, phenylethyl, substituted phenyl having the structure
- where R5 is methylthio, methylsulfonyl, methylsulfinyl, acetyl, 2-acetato, 3-acetato, methyl carbamoyl, or methoxycarbonyl and
- R3 is —CH2—CH2—CH2—, —CH2—CH2—CH2—CH2—, or —CH2—CH2—CH2—CH2—CH2—,
- or a pharmaceutically acceptable salt thereof.
4 more elements
A compound having the formula:
- in which
- R is S,
- R1 is NHR4 where R4 is hydroxypyridinyl, aminopyridinyl, alkyl hydroxypyridinyl, or haloalkyl hydroxyphenyl, and
- R2 is phenyl, benzyl, 4-methoxybenzyl, phenylethyl, or substituted phenyl having the structure
- where R5 is 3-hydroxyl, methylthio, methylsulfonyl, methylsulfinyl, acetyl, 2-acetato, 3-acetato, carbamoyl, methyl carbamoyl, or methoxycarbonyl, and
- R3 is —CH2—CH2—CH2—, —CH2—CH2—CH2—CH2—, or —CH2—CH2—CH2—CH2—CH2—,
- or a pharmaceutically acceptable salt thereof.
4 more elements
A compound having the formula:
- in which
- R is S,
- R1 is NHR4 where R4 is hydroxyphenyl or aminophenyl, and
- R2 is substituted phenyl having the structure
- where R5 4-acetato,
- R3 is —CH2—CH2—CH2—, —CH2—CH2—CH2—CH2—, or —CH2—CH2—CH2—CH2—CH2—,
- or a pharmaceutically acceptable salt thereof.
4 more elements
A compound having the formula:
- in which
- R is S,
- R1 is methoxy or —NHR4 where R4 is OH, aminophenyl, hydroxyphenyl, hydroxypyridinyl, aminopyridinyl, alkyl hydroxypyridinyl, or haloalkyl hydroxyphenyl,
- R2 is benzyl, phenylethyl, 4-methoxybenzyl, or
- where R5 is 3-hydroxyl, acetyl;
- 2-acetato, 3-acetato, carbamoyl, methyl carbamoyl, or methoxycarbonyl, and
- R3 is —CH2—CH2—CH2—, —CH2—CH2—CH2—CH2—, or —CH2—CH2—CH2—CH2—CH2—,
- or a pharmaceutically acceptable salt thereof.
5 more elements
A compound having the formula:
- in which
- R is S(O) or S(O)2
- R1 is methoxy or —NHR4 where R4 is OH, aminophenyl, hydroxyphenyl, hydroxypyridinyl, aminopyridinyl, alkyl hydroxypyridinyl, or haloalkyl hydroxyphenyl,
- R2 is benzyl, phenylethyl, or methylsulfonylphenyl and
- R3 is —CH2—CH2—CH2—, —CH2—CH2—CH2—CH2—, or —CH2—CH2—CH2—CH2—CH2—,
- or a pharmaceutically acceptable salt thereof.
3 more elements
A compound having the formula:
- in which
- R is P(O)(CH3) or P(O)(OCH3),
- R1 is methoxy or —NHR4 where R4 is OH, aminophenyl, hydroxyphenyl, hydroxypyridinyl, aminopyridinyl, alkyl hydroxypyridinyl, or haloalkyl hydroxyphenyl,
- R2 is phenyl, benzyl, 4-methoxybenzyl, phenylethyl, substituted phenyl having the structure
- where R5 is 3-hydroxyl, methylthio, methylsulfonyl, methylsulfinyl, acetyl, 2-acetato, 3-acetato, carbamoyl, methyl carbamoyl, or methoxycarbonyl and
- R3 is —CH2—CH2—CH2—, —CH2—CH2—CH2—CH2—, or —CH2—CH2—CH2—CH2—CH2—,
- or a pharmaceutically acceptable salt thereof.
4 more elements
Dependencies are inferred from the claim text.