# US 9,669,094 B2 · Methods for increasing susceptibility to apoptosis by administering an inhibitor of kallikrein 6 polypeptide activity

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- Number: US 9,669,094 B2
- Document ID: US9669094B2
- Status: Granted
- Kind: B2
- Application number: 13/962,686
- Filed: 2013-08-08
- Published: 2013-11-28
- Granted: 2017-06-06
- Earliest claimed: 2010-09-30
- Assignees: Mayo Foundation for Medical Education and Research
- Applicants: Mayo Foundation for Medical Education and Research
- Inventors: Isobel A. Scarisbrick
- Web page: https://patentgrep.com/patent/US9669094B2

## CPC

- A61K 39/39558: {against tumor tissues, cells, antigens}
- A61K 31/7088: Compounds having three or more nucleosides or nucleotides
- A61K 31/7105: Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
- A61K 31/713: Double-stranded nucleic acids or oligonucleotides
- A61K 38/4853: {Kallikrein (3.4.21.34 or 3.4.21.35)}
- A61P 35/00: Antineoplastic agents
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C12N 9/6445: {Kallikreins (3.4.21.34; 3.4.21.35)}
- C12Y 304/21008: Kallikrein (3.4.21.8) (C12Y304/21034, C12Y304/21035 take precedence)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- C12Y: ENZYMES

## Abstract

This document provides methods and materials involved in modulating a cell's ability to be resistant to apoptosis. For example, methods and materials for exposing cells to KLK6 polypeptides, or increased KLK6 polypeptide activity, to promote resistance to apoptosis are provided. In addition, methods and materials for reducing the ability of KLK6 polypeptides to promote resistance to apoptosis are provided.

## Claims

### Claim 1

A method for increasing the susceptibility of cancer cells to apoptosis, wherein said cancer cells are present within a mammal and have Kallikrein 6 (KLK6) polypeptide-induced resistance to apoptosis, wherein said method comprises:
administering an inhibitor of KLK6 polypeptide activity to said mammal under conditions wherein said inhibitor reduces the level of KLK6 polypeptide-induced resistance to apoptosis triggered by an apoptosis-inducing agent of said cancer cells within said mammal, wherein said inhibitor is an anti-KLK6 antibody.

### Claim 2 (depends on 1)

The method of claim 1, wherein said mammal is a human.

### Claim 3 (depends on 1)

The method of claim 1, wherein said method further comprises administering an anti-cancer agent to said mammal.

### Claim 4 (depends on 3)

The method of claim 3, wherein said anti-cancer agent is temazolamide, avastin, taxol, or radiation.