Dietary fiber compositions with metformin, sitagliptin, or a combination thereof for the treatment of metabolic disease
AssigneeInovoBiologic Inc.
InventorsRoland Jacques Gahler, Michael Robert Lyon, Simon Wood
Life of this patent
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Abstract
A pharmaceutical composition composed of a dietary fiber composition composed of from about 48% to about 90% (w/w) glucomannan, from about 5% to about 20% (w/w) xanthan gum, and from about 5% to about 30% (w/w) alginate in combination with at least one of metformin or sitagliptin or a combination thereof is described. The pharmaceutical composition is effective to lower elevated blood glucose levels and total blood cholesterol levels in a subject significantly more than the dietary fiber composition alone or a composition consisting of at least one of metformin or sitagliptin or a combination thereof.
Claims48
A pharmaceutical composition comprising (i) a dietary fiber composition comprising from about 48% to about 90% (w/w) glucomannan, from about 5% to about 20% (w/w) xanthan gum, and from about 5% to about 30% (w/w) alginate;
- and (ii) at least one of metformin or sitagliptin or a combination thereof, wherein the pharmaceutical composition is effective to lower elevated blood glucose levels and total blood cholesterol levels in a subject significantly more than the dietary fiber composition alone or a composition consisting of at least one of metformin or sitagliptin or a combination thereof.
A method for treating or ameliorating one or more symptoms associated with a metabolic disease or disorder, the method comprising co-administering to a subject in need thereof:
- (i) a dietary fiber composition comprising from about 48% to about 90% (w/w) glucomannan, from about 5% to about 20% (w/w) xanthan gum, and from about 5% to about 30% (w/w) alginate;
- and
- (ii) an effective amount of at least one of metformin or sitagliptin or a combination thereof, wherein the method is effective to lower elevated blood glucose levels and total blood cholesterol levels in a subject significantly more than the dietary fiber composition alone or a composition consisting of at least one of metformin or sitagliptin or a combination thereof.
A combination of:
- (i) a dietary fiber composition comprising from about 48% to about 90% (w/w) glucomannan, from about 5% to about 20% (w/w) xanthan gum, and from about 5% to about 30% (w/w) alginate;
- and
- (ii) an effective amount of at least one of metformin and/or sitagliptin;
- wherein the combination is for use in treating or ameliorating one or more symptoms associated with a metabolic disease or disorder in a subject and (i) and (ii) are for co-administration to the subject, and
- wherein the combination is effective to lower elevated blood glucose levels and total blood cholesterol levels in a subject significantly more than the dietary fiber composition alone or a composition consisting of at least one of metformin or sitagliptin or a combination thereof.
Dependencies are inferred from the claim text.