US 9,669,049 B2 · Compositions comprising gamma retrovirus vectors and methods of treating proliferative disorders

Abstract

This disclosure relates to replication competent viral vectors for treating cell proliferative disorders. The disclosure further relates to the use of such replication competent viral vectors for delivery and expression of a heterologous nucleic acid in normal and diseased tissues and methods and compositions that facilitate such delivery and expression to tissues in vivo and in vitro. The disclosure further relates to replication competent retroviral vectors for these uses and in conjunction with methods and compositions that facilitate in vivo therapeutics.

Claims27

Dependent claims

A composition comprising:

a steroid or an inhibitor of a pattern recognition receptor (PRR) or an interferon (IFN) signaling pathway inhibitor, wherein the inhibitor of PRR is an antagonist of toll-like receptor-7 (TLR7) or TLR8 or an inhibitor of downstream TLR signaling, and wherein the IFN signaling pathway inhibitor is selected from the group consisting of an anti-IFN antibody, anti-IFN receptor antibody, and a combination thereof, and
wherein the composition further comprises a recombinant replication-competent gammaretrovirus or a viral vector encoding a replication-competent gammaretrovirus.

Dependencies are inferred from the claim text.

Facts

Application

13/882,487Filed 31 Oct 2011 · us provisional application

Priority

31 Oct 2010

Published

US 2013/0323301 A15 Dec 2013

Granted

6 Jun 2017

Term ends

Not estimatedThe source records don’t support an estimate.

Classification18 codes

A61K 31/7088
Carbohydrates; Sugars; Derivatives thereof: compounds having three or more nucleosides or nucleotides
A61K 9/127
Dispersions; Emulsions: synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
A61K 31/56
Medicinal preparations containing organic active ingredients: compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives…
A61K 31/573
Substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone: substituted in position 21, e.g. cortisone,…

Family

Application61/408,623Us provisional application · filed 31 Oct 2010

Application61/408,625Us provisional application · filed 31 Oct 2010

Application61/408,875Us provisional application · filed 1 Nov 2010

Application61/415,532Us provisional application · filed 19 Nov 2010

US 2013/0323301 A1Pre-grant publication · published 5 Dec 2013

US 9,669,049 B2This patent

From the US filing history. Foreign family members aren’t listed.

Compositions comprising gamma retrovirus vectors and methods of treating proliferative disorders

Life of this patent

Compositions comprising gamma retrovirus vectors and methods of treating proliferative disorders

Life of this patent

Abstract

Claims27