Daidzein analogs as treatment for cancer
AssigneesThe Administrators of the Tulane Educational Fund, United States Department of Agriculture, Xavier University of Louisiana
InventorsGuangdi Wang, Matthew E. Burow, Stephen M. Boue, Thomas E. Wiese, Quan Jiang
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Abstract
Provided are compositions for treatment of cancers, including breast cancer, comprising at least one novel daidzein analog, as well as methods of using the same for preventing or treating cancer or tumor growth.
Claims24
A pharmaceutical composition, wherein said composition comprises at least one daidzein analog selected from the group consisting of:
- (a) 3-(4-Hydroxyphenyl)-8,8-dimethyl-8H-pyrano[2,3-f] chromen-4-one;
- (b) 3-(4-Hydroxyphenyl)-7-ethoxychromen-4-one
- (c) 3-(4-Hydroxyphenyl)-7-propoxychromen-4-one;
- (d) 3-(4-Hydroxyphenyl)-7-isopropoxychromen-4-one;
- (e) 7-Butoxy-3-(4-hydroxyphenyl)chromen-4-one;
- (f) 3-(4-Hydroxyphenyl)-7-isobutoxychromen-4-one;
- (g) 7-Cyclopentyloxy-3-(4-hydroxyphenyl)chromen-4-one;
- and
- (h) 7-Hexyloxy-3-(4-hydroxyphenyl)chromen-4-one;
- wherein said at least one daidzein analog induces less estrogenic activity than daidzein.
A method of minimizing or treating estrogen-dependent cancer or tumor growth, wherein said cancer or tumor growth is selected from breast cancer, in an animal in need thereof, comprising administering to said animal a composition comprising an effective amount of at least one daidzein analog selected from the group consisting of:
- (a) 3-(4-Hydroxyphenyl)-8,8-dimethyl-8H-pyrano[2,3-f] chromen-4-one;
- (b) 3-(4-Hydroxyphenyl)-7-ethoxychromen-4-one
- (c) 3-(4-Hydroxyphenyl)-7-propoxychromen-4-one;
- (d) 3-(4-Hydroxyphenyl)-7-isopropoxychromen-4-one;
- (e) 7-Butoxy-3-(4-hydroxyphenyl)chromen-4-one;
- (f) 3-(4-Hydroxyphenyl)-7-isobutoxychromen-4-one;
- (g) 7-Cyclopentyloxy-3-(4-hydroxyphenyl)chromen-4-one;
- and
- (h) 7-Hexyloxy-3-(4-hydroxyphenyl)chromen-4-one;
- wherein said at least one daidzein analog induces less estrogenic activity than daidzein.
Dependencies are inferred from the claim text.