Method for data reduction and calibration of an OCT-based physiological monitor

A method of estimating a blood analyte level using an optical coherence tomography (OCT) device, the method comprising:

• receiving, from an OCT device, at least two OCT scans of an area of biological tissue along a depth dimension, the at least two OCT scans obtained at different times;
• identifying at least one discontinuity in data associated with the at least two OCT scans;
• selecting one or more portions of the at least two OCT scans corresponding to the at least one discontinuity;
• and
• estimating a blood analyte level based on a comparison of the one or more portions of the at least two OCT scans with OCT calibration data.

A method of estimating a blood analyte level using an optical coherence tomography (OCT) device, the method comprising:

• receiving, from an OCT device, at least two OCT scans of an area of biological tissue along a depth dimension, the at least two OCT scans obtained at different times;
• generating a Pearson plot to indicate correlations between a plurality of OCT measurements at a plurality of portions and depths of the at least two OCT scans;
• and
• determining a first depth based on the Pearson plot;
• selecting one or more portions of the at least two OCT scans corresponding to the first depth;
• and
• estimating a blood analyte level based on a comparison of the one or more portions of the at least two OCT scans with OCT calibration data.