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US 9,664,700 B2Granted
Antibodies to risperidone and use thereof
AssigneeJanssen Pharmaceutica NV
InventorsEric Hryhorenko, Banumathi Sankaran, Thomas R. DeCory, Theresa Tubbs, Linda Colt, Maarten Vliegen, Pieter Rik Haspeslagh
Life of this patent
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Abstract
Disclosed is an antibody which binds to risperidone, which can be used to detect risperidone in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of risperidone, including multiplex detection of aripiprazole, quetiapine, olanzapine, and risperidone in a single lateral flow assay device.
Claims27
An isolated antibody or a binding fragment thereof, which binds to risperidone, comprising:
- a) a light chain variable region consisting of SEQ ID NO:3 and a heavy chain variable region consisting of SEQ ID NO:4;
- b) a light chain variable region consisting of SEQ ID NO:68, SEQ ID NO:70, or SEQ ID NO:72 and a heavy chain variable region consisting of SEQ ID NO:58, SEQ ID NO:60, SEQ ID NO:62, SEQ ID NO:64, or SEQ ID NO:66;
- c) a light chain variable region consisting of:
- SEQ ID NO:76 or SEQ ID NO:78 and a heavy chain variable region consisting of SEQ ID NO:74;
- d) a light chain variable region consisting of SEQ ID NO:86, SEQ ID NO:88, or SEQ ID NO:90 and a heavy chain variable region consisting of SEQ ID NO:80, SEQ ID NO:82, or SEQ ID NO:84;
- e) a light chain variable region consisting of SEQ ID NO:94 and a heavy chain variable region consisting of SEQ ID NO:92;
- or
- f) a light chain variable region consisting of SEQ ID NO:100 and a heavy chain variable region consisting of SEQ ID NO:96 or SEQ ID NO:98.
5 more elements
Dependencies are inferred from the claim text.