Characterization of polymer and colloid solutions
AssigneesAdvanced Polymer Monitoring Technologies, Inc., The Administrators of the Tulane Educational Fund
InventorsWayne Frederick Reed, Michael Felix Drenski, Alex Wayne Reed
Life of this patent
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Abstract
Simultaneous Multiple Sample Light Scattering systems and methods can be used for polymer stability testing and for applying stressors to polymer or colloid solutions including heat stress, ultrasound, freeze/thaw cycles, shear stress and exposure to different substances and surfaces, among others, that create a polymer stress response used to characterize the polymer solution and stability.
Claims21
A simultaneous multiple sample light scattering (SMSLS) detection device comprising:
- a plurality of light scattering batch cells, each of the light scattering batch cells configured to contain a solution;
- a plurality of stressor modules each respectively coupled to at least one of the plurality of light scattering batch cells and each respectively configured to introduce a stressor to the solutions contained in at least one of the plurality of light scattering batch cells, the plurality of stressor modules further configured to generate stressor information output data;
- a photodetector coupled to at least one of the plurality of light scattering batch cells configured to detect scattered light and generate light scattering data;
- and
- a computing device coupled to the plurality of stressor modules and the photodetector, the computing device configured to receive light scattering data from the photodetector and stressor information output data from the plurality of stressor modules, the computing device further configured to determine a time dependent response of a solution initiated by the introduction of a stressor from the light scattering data and the stressor information output data.
A method of determining a time dependent aggregation or degradation response of a biological solution to one or more stressors, the method comprising:
- introducing a biological solution to each of a plurality of light scattering cells;
- introducing, using a stressor module, one or more stressors to at least one biological solution contained in the plurality of light scattering cells;
- generating, at the stressor module, stressor information output data corresponding to the one or more stressors;
- introducing a source of incident light to the plurality of light scattering cells;
- detecting, at a photodetector, scattered light corresponding to a time dependent response in the at least one biological solution;
- generating, at the photodetector, light scattering data corresponding to the time dependent response;
- determining, at a computing device, a time dependent aggregation or degradation response of the at least one biological solution to the one or more stressors, using the light scattering data and the stressor information output data.
A simultaneous multiple sample light scattering (SMSLS) detection device comprising:
- a plurality of light scattering batch cells, each of the light scattering batch cells configured to contain a solution;
- one or more individual cell control modules respectively coupled to at least one of the plurality of light scattering batch cells and configured to introduce a solution to a respective one of the plurality of light scattering batch cells;
- a plurality of stressor modules each respectively coupled to at least one of the plurality of light scattering batch cells and each respectively configured to introduce a stressor to the solutions contained in at least one of the plurality of light scattering batch cells, the plurality of stressor modules further configured to generate stressor information output data;
- a photodetector coupled to at least one of the plurality of light scattering batch cells configured to detect scattered light and generate light scattering data;
- and
- a computing device coupled to the plurality of stressor modules and the photodetector, the computing device configured to receive light scattering data from the photodetector and stressor information output data from the plurality of stressor modules, the computing device further configured to determine a time dependent response of a solution initiated by the introduction of a stressor from the light scattering data and the stressor information output data.
Dependencies are inferred from the claim text.