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US 9,663,564 B2Granted
Vectors and methods to treat ischemia
AssigneeThe Regents of the University of California
InventorsJan Nolta, Karen Pepper, Fernando Fierro, Gerhard Bauer
Life of this patent
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Abstract
This disclosure relates to vectors, isolated cells, compositions, and methods for the treatment of critical limb ischemia and associated disorders. One aspect of the disclosure relates to a vector comprising a nucleic acid encoding a 165A isoform VEGF protein and a promoter that regulates expression of the nucleic acid encoding the VEGF.
Claims34
A vector comprising the following operatively linked to each other:
- a MNDU3 promoter, a nucleic acid encoding a 165A isoform VEGF protein or an equivalent thereof, and an enhancer.
Dependencies are inferred from the claim text.