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US 9,663,454 B2Granted
3-aryl propiolonitrile compounds for thiol labeling
AssigneesUniversite De Strasbourg, Centre National De La Recherche Scientifique
InventorsAlain Wagner, Oleksandr Koniev
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Abstract
The present invention relates to a process for labeling compounds comprising thiol moieties with 3-arylpropiolonitrile compounds, to 3-arylpropiolonitrile compounds substituted with tag moieties and to specific 3-arylpropiolonitrile linkers.
Claims1
A compound of formula (III):
- wherein
- each of R1, R2, R4, and R5 is a hydrogen atom;
- R3 is a fluorescent probe or a drug, which is bounded to the phenyl ring via a linker;
- and
- R6 is such that R6—SH is a protein containing a thiol moiety.
2 more elements
Dependencies are inferred from the claim text.