Bioactive composites of polymer and glass and method for making same
AssigneeOrthovita, Inc.
InventorsTheodore D. Clineff, Marissa M. Conrad, Matthew B. Havener, James P. Murphy, Zachary S. Szczerbinski
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Abstract
The present invention relates to a method of preparing a bioactive composite, the method comprising the steps of a) adding in a solid state a biocompatible polymer and a bioactive glass to an extruder to form an extrudable material; b) applying energy to the extrudable material to at least the melting temperature of the biocompatible polymer to melt mix the biocompatible polymer and bioactive glass; and c) extruding a bioactive composite.
Claims19
A method of preparing a bioactive composite, comprising:
- a) heating polyaryletherketone polymer particles to at least the melting temperature of the polyaryletherketone polymer to at least partially melt the polyaryletherketone polymer particles, wherein the polyaryetherketone polymer particles have a particle size ranging from 1,000 μm to 4,000 μm prior to heating, and wherein the polyaryletherketone polymer has a molecular weight ranging from 70,000 to 120,000 Daltons prior to heating;
- b) adding alkali-containing bioactive glass particles to the at least partially melted polyaryletherketone particles,
- wherein the alkali-containing bioactive glass particles have a particle size ranging from 1 μm to 500 μm;
- and
- c) extruding a bioactive composite, wherein the polyaryletherketone polymer is present in an amount of 70% to 85% by weight of the extruded bioactive composite, and wherein the alkali-containing bioactive glass particles is present in an amount of 15% to 30% by weight of the extruded bioactive composite.
A method of preparing a homogeneous bioactive shaped body, comprising:
- a) heating polyaryletherketone polymer particles to at least the melting temperature of the polyaryletherketone polymer to at least partially melt the polyaryletherketone polymer particles, wherein the polyaryetherketone polymer particles have a particle size ranging from 1,000 μm to 4,000 μm prior to heating, and wherein the polyaryletherketone polymer has a molecular weight ranging from 70,000 to 120,000 Daltons prior to heating;
- b) adding alkali-containing bioactive glass particles to the at least partially melted polyaryletherketone polymer particles, wherein the alkali-containing bioactive glass particles have a particle size ranging from 1 μm to 500 μm;
- and
- c) extruding homogeneous pellets of polyaryletherketone polymer and alkali-containing bioactive glass particles, wherein the polyaryletherketone polymer is present in an amount of 70% to 80% by weight of the homogeneous pellets, and wherein the alkali-containing bioactive glass particles are present in an amount of 20% to 30% by weight of the homogeneous pellets;
- and
- d) injection molding the homogeneous pellets to form the homogeneous bioactive shaped body.
A method of preparing a bioactive composite, comprising:
- a) heating polyetheretherketone (PEEK) polymer particles to at least the melting temperature of the PEEK polymer to at least partially melt the PEEK polymer particles, wherein the PEEK polymer particles have a particle size ranging from 1,000 μm to 4,000 μm prior to heating, and wherein the PEEK polymer has a molecular weight ranging from 100,000 to 120,000 Daltons prior to heating;
- b) adding alkali-containing bioactive glass particles to the at least partially melted PEEK polymer particles, wherein the bioactive glass particles have a particle size range from 1 μm to 500 μm;
- and
- c) extruding a bioactive composite, wherein the PEEK polymer is present in an amount of 70% to 80% by weight of the extruded bioactive composite, and wherein the alkali-containing bioactive glass particles is present in an amount of 20% to 30% by weight of the extruded bioactive composite.
Dependencies are inferred from the claim text.