Method for drug loading hydroxyapatite coated implant surfaces

A method for loading a hydroxyapatite coated implant with a therapeutic agent, comprising:

• providing an implant;
• coating the implant with a metal selected from the group consisting of TiO2, TiO, TiCrO2, Ti2O3, Ti3O5, SiO2, MgO2, AlO2, and CrO2;
• applying a hydroxyapatite coating on a surface of the implant;
• thereafter placing the hydroxyapatite coated implant in a solution including the therapeutic agent;
• heating the hydroxyapatite coated implant and the solution to a temperature of about 60° C. to about 100° C.;
• and
• applying pressure to the hydroxyapatite coated implant and solution of about 2 bar to about 10 bar to load the hydroxyapatite coated implant with the therapeutic agent for improved therapeutic agent delivery at an implant site;
• and
• thereafter removing the implant from the solution after about 5 minutes.

A method for loading a hydroxyapatite coated implant with a therapeutic agent, comprising the steps of:

• providing an implant;
• applying a hydroxyapatite coating on a surface of the implant;
• contacting the hydroxyapatite coated implant with a solution including the therapeutic agent;
• heating the hydroxyapatite coated implant and solution to a temperature of about 60° C. to about 100° C.;
• and
• applying pressure to the hydroxyapatite coated implant and solution of about 2 bar to about 10 bar to load the hydroxyapatite coated implant with the therapeutic agent for improved therapeutic agent delivery at an implant site;
• and
• thereafter removing the implant from the solution after about 5 minutes.