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US 9,657,278 B2Granted
Methods to produce bunyavirus replicon particles
AssigneeStichting Dienst Landbouwkundig Onderzoek
InventorsJeroen Alexander Kortekaas, Robertus Jacobus Maria Moormann
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Abstract
The invention relates to methods of producing infectious bunyavirus replicon particles. These bunyavirus replicon particles are safe and can be used outside a biosafety containment. The invention further relates to recombinant bunyavirus replicon particles and uses of these recombinant bunyavirus replicon particles.
Claims10
A non-spreading recombinant bunyavirus replicon particle, comprising:
- a bunyavirus L genome segment
- a bunyavirus S genome segment or part of a bunyavirus S genome segment comprising at least the N gene and the 3′ and 5′ UTRs;
- and, optionally, when a bunyavirus M genome segment is to be present,
- a bunyavirus M genome segment from which the GnGc coding region has been functionally inactivated, resulting in a non-spreading bunyavirus replicon particle.
1 more element
Dependencies are inferred from the claim text.