Amine compound and use thereof for medical purposes
AssigneeMitsubishi Tanabe Pharma Corporation
InventorsMaiko Hamada, Kaoru Tashiro, Hiroshi Sakashita, Masatoshi Kiuchi, Shuzo Takeda, Kunitomo Adachi
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Abstract
The present invention provides a compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION, which has a superior peripheral blood lymphocyte decreasing action, and is useful for the treatment or prophylaxis of autoimmune diseases; prophylaxis or suppression of resistance or acute rejection or chronic rejection of transplantation of organ or tissue; treatment or prophylaxis of graft-versus-host (GvH) disease due to bone marrow transplantation; or treatment or prophylaxis of allergic diseases.
Claims13
An amine compound represented by the following formula (I)
- wherein
- R1 is a hydrogen atom or P(═O)(OH)2,
- V is a C1-4 alkylene or a C2-4 alkenylene,
- R2 is a hydrogen atom, or a C1-4 alkyl optionally substituted by a hydroxy group or a halogen atom,
- R3 and R4 are the same or different and each is a hydrogen atom or a C1-4 alkyl,
- X is a single bond, an oxygen atom, a sulfur atom, methylene, —CO—, —SO—, —SO2— or —NR5—
- wherein R5 is a hydrogen atom or a C1-4 alkyl optionally having substituent(s),
- A1 and A2 are the same or different and each is a single bond, an oxygen atom, a sulfur atom, —CO—, —SO—, —SO2— or —NR6— wherein R6 is a hydrogen atom, a C1-6 alkyl optionally having substituent(s), a C1-7 acyl optionally having substituent(s) or a C2-7 alkoxycarbonyl,
- Y is C═O,
- B1 and B2 are the same or different and each is a single bond, a C1-10 alkylene optionally having substituent(s), a C2-10 alkenylene optionally having substituent(s) or a C2-10 alkynylene optionally having substituent(s),
- C1 and C2 are the same or different and each is a hydrogen atom, a halogen atom, a C6-10 aryl optionally having substituent(s), a heteroaryl with 5 to 10 ring-constituting atoms optionally having substituent(s), which contains 1 or 2 nitrogen atoms, 1 or 2 oxygen atoms or 1 or 2 sulfur atoms as the ring-constituting atom(s), a C3-7 cycloalkyl optionally having substituent(s), which is optionally fused with benzene optionally having substituent(s), or a heterocycloalkyl with 5 to 7 ring-constituting atoms optionally having substituent(s), which contains 1 or 2 nitrogen atoms or 1 or 2 oxygen atoms as the ring-constituting atoms, and is optionally fused with benzene optionally having substituent(s),
- D is a hydrogen atom, a halogen atom or a C1-4 alkyl optionally having substituent(s),
- m is 0 or 1, and
- n is 0 or 1,
- or a pharmaceutically acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.