Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof

A method for making a compound of Formula (54)

• comprising
• contacting a compound of Formula (55)
• with a compound of Formula (56)
• in a solvent containing an additional base and a transition metal catalyst to provide the compound of Formula (54);
• wherein:
• R14 is selected from —OH and —OR17;
• R16 is selected from —OH, —H, and —OR17;
• the 6,7 bond, the 7,8 bond, and the 8,14 bond are each independently a single bond or a double bond, with the provisos that (1) if the 6,7 bond is a double bond, then the 7,8 bond is a single bond, (2) if the 7,8 bond is a double bond, then the 6,7 and 8,14 bonds are each a single bond, and (3) if the 8,14 bond is a double bond, then the 7,8 bond is a single bond and R16 is not present;
• R15 is selected from —OH, —H, —OR17, ═O, and ═CH2 with the proviso that if the 6,7 bond is a double bond, then R15 is selected from —OH, —H, and —OR17;
• R22 is —OC(O)X;
• X is selected from —Cl, —Br, and —I;
• and
• R17 is an oxygen protecting group.