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US 9,656,985 B2Granted
Surfactant-enabled transition metal-catalyzed chemistry
AssigneeMyCell Technologies, LLC
InventorVolker Berl
Life of this patent
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Abstract
In one embodiment, the present application discloses mixtures comprising (a) water in an amount of at least 1% wt/wt of the mixture; (b) a transition metal catalyst; and (c) one or more solubilizing agents; and methods for using such mixtures for performing transition metal mediated bond formation reactions.
Claims16
A mixture comprising
- (a) water in an amount of at least 1% wt/wt of the mixture, and further comprising one or more non-aqueous solvent or solvent mixtures selected from the group consisting of methanol, ethanol, propanol, isopropanol, butanol(s), n-butanol, acetone, ethyl acetate, methyl acetate, THF, acetonitrile, formic acid, acetic acid, ethyleneglycol or PEGs, dioxane, MIBK, MEK, DMSO, DMF, DMA, NMP or mixtures thereof;
- (b) a transition metal catalyst;
- and
- (c) a solubilizing agent having the formula
- Y1-L1-Z
- wherein Z is a hydrophobic group,
- and Y1-L1- has the formula:
- wherein n is an integer selected from 2-10,
- k is 16-20, and
- Y7 is methyl.
7 more elements
A method for performing a transition metal mediated bond formation, the method comprising:
- contacting a coupling substrate with a mixture comprising:
- (a) water in an amount of at least 1% wt/wt of the mixture, and further comprising one or more non-aqueous solvent or solvent mixtures selected from the group consisting of methanol, ethanol, propanol, isopropanol, butanol(s), n-butanol, acetone, ethyl acetate, methyl acetate, THF, acetonitrile, formic acid, acetic acid, ethyleneglycol or PEGs, dioxane, MIBK, MEK, DMSO, DMF, DMA, NMP or mixtures thereof;
- (b) a transition metal catalyst;
- and
- (c) a solubilizing agent having the formula
- Y1-L1-Z
- wherein Z is a hydrophobic group,
- and Y1-L1- has the formula:
- wherein n is an integer selected from 2-10, k is 16-20, and Y7 is methyl;
- under conditions appropriate to form a bond between a first atom of the coupling substrate and a second atom of a member selected from (i) the coupling substrate and (ii) a coupling partner.
7 more elements
Dependencies are inferred from the claim text.