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US 9,655,844 B2Granted
Biocompatible polysaccharide-based hydrogels
AssigneeThe Johns Hopkins University
InventorsSharon Gerecht, Yu-I Shen, Chia Chi Ho, Guoming Sun
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Abstract
Modified polysaccharides and crosslinked modified polysaccharide compositions are described. Methods of using the crosslinked modified polysaccharide compositions to deliver proteins, oligonucleotides, or pharmaceutical agents are also disclosed.
Claims31
A crosslinked hydrogel composition comprising
- at least 80% of a polysaccharide with at least one monomer having at least one substituted hydroxyl group, wherein the substituted hydroxyl group has the formula (III), and wherein the degree of substitution of formula (III) on the polysaccharide is less than about 0.2;
- and
- polyethylene glycol diacrylate,
- wherein
- formula (III) is
- —O1—C(O)NR7—CH2CH═CH2
- and O1 is the oxygen atom of said substituted hydroxyl group and R7 is hydrogen or C1-C4 alkyl,
- wherein the polysaccharide is dextran, and
- wherein the polysaccharide is crosslinked by reaction with the polv(ethvlene glycol) diacrylate.
6 more elements
A crosslinked composition comprising
- a polysaccharide with at least one monomer having at least one substituted hydroxyl group,
- wherein the polysaccharide is crosslinked by reaction with poly(ethylene glycol) diacrylate;
- and
- wherein the polysaccharide includes a first substituted hydroxyl group of formula (I) and a second substituted hydroxyl group of formula (II), wherein formula (I) and formula (II) are different, the degree of substitution of formula (I) on the polysaccharide is less than about 0.2;
- and the first and second substituted hydroxyl groups may be on the same or different monomer;
- wherein
- formula (I) is
- —O1—X
- where O1 is the oxygen atom of said substituted hydroxyl group, and X is a crosslinkable moiety having a double bond;
- and
- formula (II) is
- Y—(CR2R3)n—CO2H
- Y is −O1- or —O1C(O)—, or —O1C(O)NR1— where O1 is the oxygen atom of said substituted hydroxyl group, and R1 is hydrogen or C1-C4 alkyl, n=1, 2, 3, or 4, R2 and R3 may be independently hydrogen, C1-C4 alkyl, or may combine to form a 3-6 membered ring, and when n>1, R2 and R3 on different carbon atoms may form a 3-6 membered ring;
- and the polysaccharide is dextran.
11 more elements
Dependencies are inferred from the claim text.