Back to results
US 9,650,670 B2Granted
Capacitive feedback (transimpedance) amplifier
AssigneeThe Regents of the University of California
InventorsJungsuk Kim, William Dunbar
Life of this patent
Estimating the term…
Abstract
A polynucleotide sequencer comprising an integrated and multiplexed network of patch clamp capacitive integrator-differentiator amplifiers with small feedback capacitors using pseudo-resistors.
Claims13
A patch clamp amplifier, comprising:
- an integrating operational amplifier having a first inverting input for receiving current from a nanopore sensor, said integrating operational amplifier further having a first non-inverting input and a first output;
- a feedback capacitor connecting said first output to said first inverting input;
- a feedback impedance in parallel with said feedback capacitor;
- a differentiator operational amplifier having a second inverting input, a second non-inverting input, and a second output;
- a first input capacitor connecting said second inverting input to said first output;
- a first input impedance in parallel with said first input capacitor;
- a second input capacitor connecting said second non-inverting input to said first non-inverting input;
- a second input impedance in parallel with said second input capacitor;
- a first resistor connecting said second output to said second inverting input;
- and
- a second resistor connecting said second non-inverting input to ground;
- wherein said feedback impedance is provided by a pseudo-resistor or an on-chip poly resistor.
9 more elements
Dependencies are inferred from the claim text.