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US 9,650,446 B2Granted
Heterodimeric proteins
AssigneeXencor, Inc.
InventorsGregory Moore, Matthew Bernett, Rumana Rashid, John Desjarlais
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Abstract
The invention provides novel heterodimeric proteins including heterodimeric antibodies.
Claims9
A heterodimeric antibody comprising:
- a) a first heavy chain comprising:
- i) a first variant Fc domain;
- and
- ii) a single chain Fv region (scFv) that binds a first antigen, wherein said scFv region comprises a first variable heavy chain, a variable light chain and a charged scFv linker, wherein said charged scFv linker covalently attaches said first variable heavy chain and said variable light chain;
- and
- b) a second heavy chain comprising a VH-CH1-hinge-CH2-CH3 monomer, wherein VH is a second variable heavy chain and CH2-CH3 is a second variant Fc domain;
- and
- c) a light chain;
- wherein said second variant Fc domain comprises amino acid substitutions N208D/Q295E/N384D/Q418E/N421D,
- wherein said first and second variant Fc domains each comprise amino acid substitutions E233P/L234V/L235A/G236del/S267K;
- and
- wherein said first variant Fc domain comprises amino acid substitutions S364K/E357Q and second variant Fc domain comprises amino acid substitutions L368D/K370S, wherein numbering is according to the EU index as in Kabat.
9 more elements
Dependencies are inferred from the claim text.