Method for treating bleeding disorders
AssigneeBayer HealthCare LLC
InventorsMyung-Sam Cho, Sham-Yuen Chan
Life of this patent
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Abstract
The invention concerns glycosylated proteins having human factor VIII activity. In a preferred embodiment, the protein is glycosylated with oligosaccharides that include an alpha-(2,6)-linked sialic acid and a bisecting GlcNAc linked to a core beta-mannose.
Claims2
A method of treating hemophilia A comprising administering to a human in need thereof a therapeutically effective amount of a pharmaceutical composition comprising an isolated glycosylated protein having factor VIII procoagulant activity comprising an N-linked oligosaccharide having an alpha-(2,6)-linked sialic acid and a pharmaceutically acceptable adjuvant.
A method of treating hemophilia A comprising administering to a human in need thereof a therapeutically effective amount of a pharmaceutical composition comprising a glycosylated protein having factor VIII procoagulant activity comprising the amino acid sequence of SEQ ID NO:
- 1 and an N-linked oligosaccharide having an alpha-(2,6)-linked sialic acid and a pharmaceutically acceptable adjuvant.
Dependencies are inferred from the claim text.