Method for inhibiting platelet interaction with biomaterial surfaces
AssigneeMedtronic ATS Medical, Inc.
InventorBrian Pederson
Life of this patent
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Abstract
A method for passivating a biomaterial surface includes modifying proteinaceous material disposed at the biomaterial surface. The passivation may be effectuated by exposing the biomaterial surface to therapeutic electrical energy in the presence of blood or plasma.
Claims14
A method for passivating a biomaterial surface, said method comprising:
- exposing said biomaterial surface to therapeutic electrical energy in the presence of blood or plasma prior to implantation within a human body of an object on which said biomaterial surface is located;
- and
- causing proteinaceous material in the blood or plasma to adhere to said biomaterial surface.
A method for passivating a biomaterial surface, said method comprising depositing modified proteinaceous material at said biomaterial surface prior to implantation with a human body of an object on which said biomaterial surface is located.
A method for passivating a biomaterial surface, said method comprising:
- (a) exposing a quantity of blood or plasma to therapeutic electrical energy;
- (b) subsequent to step (a), depositing proteinaceous material from said quantity of blood or plasma on said biomaterial surface;
- (c) subsequent to step (b), implanting in a human body an object on which said biomaterial surface is located;
- and
- (d) subsequent to step (c), inhibiting aggregation of blood platelets at said biomaterial surface by the deposited proteinaceous material.
A method for inhibiting aggregation of blood platelets at a biomaterial surface, said method comprising:
- exposing said biomaterial surface to therapeutic electrical energy in the presence of blood or plasma prior to implantation within a human body of an object on which said biomaterial surface is located;
- and
- causing proteinaceous material in the blood or plasma to adhere to said biomaterial surface to thereby inhibit aggregation of blood platelets at said biomaterial surface.
A method for passivating a biomaterial surface, said method comprising modulating the preferential adsorption of blood proteins to said biomaterial surface by exposing said blood proteins to therapeutic electrical energy prior implantation within a human body of an object on which said biomaterial surface is located.
Dependencies are inferred from the claim text.