Magnetic resonance imaging cell labeling methods and compositions
AssigneesUniversity of Pittsburgh—Of the Commonwealth System of Higher Education, Carnegie Mellon University
InventorsEric T. Ahrens, David Schwartzman
Life of this patent
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Abstract
The disclosure provides, in part, fluorocarbon imaging reagents and methods for image-guided treatment and/or diagnosis of a subject with a condition associated with an inflammatory response in an internal organ. The disclosure additionally provides methods for image-guided treatment of myocardial infarction (MI) in a subject.
Claims36
A method for image-guided treatment of a subject with a condition associated with an inflammatory response in an internal organ comprising:
- a) administering a 19F MRI fluorocarbon imaging reagent to said subject to label inflammatory cells,
- b) performing 19F MRI of the subject to detect labeled inflammatory cells,
- c) identifying, for the internal organ, boundaries between healthy and affected tissue in the subject using the 19F MRI data from step (b), and
- d) administering a medicament to the internal organ based on data obtained in step (c) to treat the condition.
A method for image-guided treatment of a subject with a condition associated with an inflammatory response in an internal organ comprising:
- a) providing 19F MRI data identifying boundaries between healthy and affected tissue of the internal organ of the subject, which subject was previously administered a 19F MRI fluorocarbon imaging reagent to label inflammatory cells, and
- b) administering a medicament to the internal organ based on data obtained in step (a) to treat the condition.
A method for image-guided diagnosis of a subject with a condition associated with an inflammatory response in an internal organ comprising:
- a) administering a 19F MRI fluorocarbon imaging reagent to said subject to label inflammatory cells,
- b) performing 19F MRI of the subject to detect labeled inflammatory cells,
- c) identifying, for the internal organ, boundaries between healthy and affected tissue in the subject using the 19F MRI data from step (b), and
- d) performing a diagnostic procedure on the internal organ based on data obtained in step (c).
Dependencies are inferred from the claim text.